![]() 2 Its presence or absence gives a patient the ‘positive’ or ‘negative’ status in typical transfusion nomenclature. The Rh blood group system is comprised of over 50 different antigens, but the most significant is the D antigen, as it is the most immunogenic. These individuals produce strong anti-H and anti-AB antibodies, meaning that they can only be transfused with other O h red blood cells. While ABO genetics means that a child’s blood group can be statistically inferred from the genotype or phenotype of their parents, subgroups and rare alleles mean that accuracy is not guaranteed.įor example, the Bombay phenotype (O h) occurs when the patient lacks the ABO antigen precursor known as the H antigen, leading to no ABO antigen production. Most of these subgroups are not clinically important. There are subgroups within the ABO system, caused by inherited mutations to the ABO alleles, and related genes.
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